Graves’ Disease Frequency and Clinical Patterns In Khartoum Teaching Hospital January - July 2004
Graves’ Disease Frequency and Clinical Patterns In Khartoum Teaching Hospital January - July 2004
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Date
2015-04-06
Authors
Mohammed, Khanssa
Journal Title
Journal ISSN
Volume Title
Publisher
UOFK
Abstract
This is a prospective cross sectional descriptive study
performed at Khartoum Teaching Hospital clinics in the period
from January 2004 to July 2004.
Aims: To diagnose patients with Graves’ disease among thyrotoxic
patients by detection of TSI in their sera, to assess the frequency of
Graves’ disease, and to study the clinical patterns of Graves’
disease.
Patients & methods: Forty-nine patients with thyrotoxicosis
(confirmed by laboratory investigations) were studied. Data was
collected using designed questionnaire. TSI in the sera was
detected by RIA. Frequency of Graves’ disease was determined.
Symptoms and signs of the patients with TSI were studied.
Results: Out of Forty-nine patients, thirty-four patients were
found to have detectable significant level of TSI. Frequency of
Graves’ disease amongst the patients was 69.4% . Main symptoms
were dislike to hot weather (70%) , palpitation (35%), tremor (24%)
infertility (20%), irritability (35%), fatigability (10%).
Main signs were onycholysis (73%), proptosis (64%), tachycardia
(44%) diffuse Goiter (30%), palmer erythema and anemia (7%),
thyroid acropachy and pretibial myxodema (0%)
Conclusion: Graves’ disease is the commonest cause of
hyperthyroidism in patients with thyrotoxicosis in K.T.H.
Diagnosis of Graves’ disease is done by detection of TSI in the
patient serum. Dislike to hot weather and palpitation are major
symptoms of Graves’. Proptosis is a major sign of Graves’.
Onycholysis is common in Graves’ disease.
Recommendations: Accurate diagnosis of Graves’ disease by high
clinical suspicion and TSI detection in the patient serum. More
studies for evaluation of radioactive iodine therapy in Sudan in
order to extend it’s use in management of Graves’ disease.
Description
Keywords
Graves’ Disease,Thyroid, stimulating, imrnunoglobulin, (TSI),