Level Of Serum Uric In Patients With Preeclampsia Compared To Controls

Abstract

Preeclampsia is an important cause of both fetal and maternal morbidity and mortality worldwide and in Sudan. Early diagnosis and follow up will significantly improve the outcome of the disease. Serum uric acid is widely used for diagnosis and follows up of preeclampsia. This study is conducted to compare serum uric acid in patients with preeclampsia with normal control. Objective: The objective of this study is to estimate the serum uric acid in preeclampsia and in normal pregnancy. It aims also to detect if there is any significant difference, and to relate serum uric acid to the severity of the disease. Materials and Methods: This is a case-control hospital based study covering 100 (50 case/50 control) pregnant ladies in their third trimester in the unit of obstetric and gynaecology in KTH. The study was conducted in the period from September 2009 to Jan 2010. Clinical data was obtained from patients through questionnaire. Serum uric acid was analyzed in the laboratory at the same hospital. Results: the mean serum uric acid of the control group was 4.47 mg/dL. (within the normal range). v The mean for the case group is 7.35 mg/dL (above the normal range). P value = 0.000 statistically is highly significant. Serum uric acid correlate well with the severity of disease. Conclusions and Recommendations: Preeclampsia is associated with rise in serum uric acid level. The higher the blood pressure in preeclampsia the higher the rise in serum uric acid level. It is recommended that serum uric acid measurement is included in the follow up of preeclampsia. Serum uric acid level should be used as a predictive factor for preeclampsia.