Development of Kinetic and Spectrophotometric Methods for Determination of Dopamine Hydrochloride in Bulk and Injectable Form

Abstract

Dopamine formulations are indicated for cardiogenic shock in infarction or cardiac surgery (BNF).It is ineffective orally in large part because it is substrate for both MAO and COMT. Thus, it is used intravenously. Methods used for analysis of dopamine HCl injection are either sophisticated (liquid Chromatography in official compendia, e.i. B.p and USP) or utilizing techniques that is unobtainable for the quality control laboratories in Sudan (Flow injection analysis technique). In between, several reported spectrophotometric methods were adopted for determination of dopamine HCl in dosage form. The prime objective of this research work is to adopt precise, simple, cost-effective, specific and sensitive method for the assay of dopamine HCl , utilizing a UV Spectrophotometry technique which is highly demanded in pharmaceutical industry sector in Sudan, to be used for routine analysis, as it is highly economical with respect to robustness, reagent consumption