Serologic relationship and antigenic dominance among five Aujeszky’s disease virus isolates

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Saeed, Abdelwahid
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University of Khartoum
The serologic relationship and antigenic dominance among five Aujeszky’s disease virus (ADV) isolates, designated VBA1, VBA2, VBA3, mA1p and CD, was studied using homologous and heterologous antigens and sera. Cross-serum neutralization test (C-SNT) was used to measure antibody responses to the virus. Generally, close serologic relationships among ADV isolates were noted. Non-significant (P<0.05) variations in the relationship between any two viruses were observed. However, the highest bilateral relationship was observed between VBA2 and VBA3 and between VBA2 and CD isolates of the virus. The antigenic dominance of some viruses over the others was detected with non-significant (P<0.01) levels, although the higher antigenic dominance was observed for CD over VBA3 and mA1p over VBA3 also. In conclusion, neither major serological variations nor antigenic dominance among the five ADVs studied were detected in the present study, hence grouped as one serologic type.
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Aujeszky’s disease virus, antigen, antibody, cross-neutralization