The Activity Of Commiphora Myrrhagainst Between Β-Blockers And Chemotherapeutic Agents

Abstract

This study done in Khartoum state, Clinical isolates were recovered from wounds of Sudanese patients visiting Khartoum Teaching Hospital and National Health Laboratory during January 2005 – September 2007. A total of 200 bacterial strains wereisolated and identified. The study showed that 62of the isolates were Staphylococcus aureus, 44 Escherichia coli, 34 Pseudomonas aeruginosa, 30 Klebsiella pneumoniae,and 30 Proteus vulgaris.The study proved the volatile oil extract from Commiphora myrrh effective on clinical isolates especially against Staphylococcus aureus. The broth dilution method was used for determing the activity of the extract against standard organisms and clinical isolates. Five concentrations (100, 50, 25, 12.5, 6.25mg/ml and control) of purified volatile oil of Commiphora myrrhwere tested to determine their effects against standard organisms and clinical isolates that were recovered from patient wounds. The results revealed that the highest activity was shown against Staphylococcus aureus. Both 100 mg/ml and 50mg/ml(100%) inhibited the growth of all species. In contrast 6.25mg/ml showed no activity for all organisms. The effect of 25 mg/ml and 12.5mg/ml varied between different species. The study proved that the antibacterial activity of the volatile oil extract from Commiphora myrrhagainst clinical isolates was high. These findings should stimulate the search for novel natural antibacterial agent.