The Hypoglycemic Effect Of Cinnamomum Verum (Elgerfa) In Rats
The Hypoglycemic Effect Of Cinnamomum Verum (Elgerfa) In Rats
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Date
2015-04-15
Authors
Faroug, Dalal
Journal Title
Journal ISSN
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Publisher
UOFK
Abstract
This study tested the anti-diabetic and hypoglycemic effect of the
Cinnamon which is available in Sudan. Cinnamon is use in so many
countries for treatment of bacterial and fungal disease, cold influenza and
as antioxidant agent. Recently people discovered that Cinnamum cassia
induced hypoglycemia in patient with type2 diabetes mellitus. C.cassiais
closely like C. verum(the species found in Sudanese markets). This study
was carried out in Wister albino rats.
In experiment (1), the rats were divided into three groups A, B and C; each group consisted of six rats. The serum glucose level of all
rats (A, B and C) was measured at 0h after 18 hour fasting then they were
injected with glucose solution 50% concentration to induce hyperglycemia.
Group B after glucose load was treatedorally with Glibenclamide as
standard drug. Group C which was also hyperglycemic rats was treated
orally with C. verum(1g/kgBwt), then the plasma glucose level was
measured after 1, 2 and 4h.
In experiment (2): Normoglycemicfasting rats were divided into
two groups D and E, each group consisted of six rats. After 18 hours
fasting glucose level of both group (D and E) was measured at 0h. Then
the rats of group D received orally C. verumin dose of 1g/kgBwt while
rats of group E were untreated control group. Then serum glucose level of
both groups was measured at hour 1, 2 and 4.
Experiment 1 showed that Glibenclamide lowered significantly
serum glucose level at hour 1, 2 and 4 when compared to control group
xi
while C. verumlowered significantly serum glucose level at hour 2 and
nonsignificantly at hour 4.
Experiment (2) showed administration of C. verumto
normoglycemic rats lowered significantly serum glucose level at hour 4
(P≤0.01) and nonsignificantly at hour 1 and 2.
This experiment showed that Cinnamum sp which found in all
market in Sudan has antidiabetic and hypoglycemic effect in
hyperglycemic rats. Also the same dose has hypoglycemic effect in
normoglycemic rats.
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Keywords
HYPOGLYCEMIC,EFFECT,CINNAMOMUM VERUM, RATS