THE HYPOGLYCAEMIC AND ANTI-DIABETIC EFFECTS OF P.ANISUM
THE HYPOGLYCAEMIC AND ANTI-DIABETIC EFFECTS OF P.ANISUM
No Thumbnail Available
Date
2015-04-10
Authors
Abdul Gayoum, Mujahid
Journal Title
Journal ISSN
Volume Title
Publisher
UOFK
Abstract
The anti-diabetic and hypoglycemic effects of P.ansium, which is used
traditionally world wide for the treatment of several disease were studied. The
effect of the plant on the plasma glucose, total protein, albumin, bilrubin,
cholesterol, triglyceride ,enzyme (GOT, GPT and alkaline phosphatase) and
concentrations of N+ and K+ were evaluated in diabeticand normal rats.
Adult male Wister albino rats were usedin the present work. The diabetes was
induced by injection of streptozotocin. The experiment extended over three
weeks .Rats were divided into four groups each group consisted of 6 rats :
Group A was control group and contained normal rats , fed rat diet only
(63g/day), Group B contained normal rats fed P.anisumpowder which replaced
15% of diet to examine the P.anisumeffects on normal rats, Group C contained
diabetic induced rats fed diet only (63g/day) and Group D contained diabetic
induced rats fed P.anisumpowder which replaced 15% of rat's diet to examine
the effects of feeding P.anisumon diabetic rats.
The addition of 15% of P.anisumto the diet lowered significantly the plasma
glucose level of diabetic rats at 0,1,2,3 h after overnight fasting when compared
with diabetic fed diet only.
The feeding of P.anisumto normal rats, lowered the glucose level at 2h and
elevated it significantly at 3h butthe difference was small.
The feeding P.anisumhad no significant effect on plasma total protein,
albumin, GOT, GPT , alkaline phosphatase , cholesterol , triglyceride, bilrubin,
N
+
and K
+
concentrations in both normal and diabetic rats .Thus it could be
concluded that P.anisumis unlikely to be toxic.
It was noticed in this study, that the induction of diabetes in rats by
ix
streptozotocin caused significant elevation of plasma glucose level ,cholesterol
and urea ; and lowered significantly plasma albumin , triglycerides and the body
weight but the induced diabetes had no significant effect in plasma total protein
,GOT,GPT, alkaline phosphatase, bilrubin creatinine , Na
+
or K
+
Therefore ,it can be concluded P.anisumis promising antidiabetic agent and
could be used to lower hyperglycemia in diabetic patient.
Description
Keywords
ANISUM,HYPOGLYCAEMIC,abnormality , glucose, toleranc