Some Aspects of Short Term Thiopentone Sodium Anaesthesia With or Without Selected Pre-Anaesthetic Medications in Goat Kids.

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Date
2015-06-23
Authors
Mohamed Ahmed Hassan Ghorashi., Ghorashi
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Publisher
UOFK
Abstract
This investigation was conducted using 18 healthy crossbred goat kids. Acepromazine (ACP) 0.2 mg/kg, Diazepam (DZ) 0.5 mg/kg and xylazine (XY) 0.l mg/kg were used as pre-anaesthetic medications and were intravenously injected. Thiopentone sodium (TH) was used as an induction agent at three different doses namely 10, 15 and 20 mg/kg and it was injected as intravenous bolus in all experiments. Respiratory rate, heart rate and rectal temperature were monitored using standard methods. The different phases of anaesthesia (induction of anaesthesia, anaesthesia phase, narcosis phase, lateral recumbence phase, sternal recumbence phase, standing phase and total recovery time) were subjectively monitored. Regaining time of the different reflexes together with the relationship between these reflexes was also subjectively studied. An attention was also paid to the effect of changing the dose of TH sodium with or without premeditations on the different phases of anaesthesia. Apnoea was found to occur following induction of anaesthesia with the different anaesthetic protocols tested. Xylazine containing protocols were found to be associated with significantly longer durations of apnoea compared to the other anaesthetic protocols. : The respiratory rate was found to be significantly depressed following induction of anaesthesia with 9 protocols out of the 12 protocols tested. Induction of anaesthesia with the different protocols using TH sodium with or without premeditations resulted in a significant tachycardia, which persisted in five protocols for the whole course of anaesthesia until full recovery was regained. Rectal temperature was found to be non-significantly affected except when ACP was used in combination with thiopentone sodium 15 or 20 mg/kg. Premedication of animals with ACP 0.2 mg/kg, DZ. 0.5 mg/kg or XY0.1 mg/kg resulted in prolongation of the anaesthesia phase and increased percentage this phase to the total recovery time. Non-significant differences in durations of narcosis phase were encountered in 6 groups of the premedicated animals out of the 9 groups tested compared with the non-premedicated groups. Incorporation of the three pre-anaesthetic medications in the anaesthetic protocols resulted in reduction of the percentage of the narcosis phase to the total recovery time. Premedication with ACP (0.2 mg/kg), DZ (0.5 mg/kg) or XV (0.l mg/kg) before induction of anaesthesia with TH sodium resulted in an inconsistent finding with regard to the durations of the lateral recumbence phase, but they caused an increase in the percentage of this phase to the total recovery time. Premedication with ACP 0.2 mg/kg DZ 0.5 mg/kg or XY 0.1 mg/kg resulted in non-significantly longer durations of sternal recumbence and standing phases compared with the non-premedicated groups. Generally, the usage of the three premedications resulted in significantly prolonged total recovery time. An exception was encountered when ACP 0.2 mg/kg was used in combination with TH sodium 10 mg/kg were the prolongation of the total recovery time was found a non-significant value. The mean regaining time of the swallowing reflex was found to be the shortest among the other reflexes in all groups. Pedal and palpebral reflex showed a significant difference in their regaining time following induction of anaesthesia with only one protocol out of the 12 protocols tested. Inconsistent results were obtained regarding the relationship between palpebral, pedal reflexes and the other reflexes tested. Changing the dose of TH sodium from 10 to 15 or from 15 to 20 mg/kg in different experiments conducted resulted in a significant prolongation of the anaesthesia phase together with an increase in the percentage of this phase to the total recovery time. An overall look revealed non-significant differences in durations of narcosis phase, lateral recumbence phase, sternal recumbence phase and standing phase as a result of changing the dose of TH sodium from 10 to15 or from 15 to 20 mg/kg. In 10 protocols out of the 12 protocols tested, changing the dose of TH sodium from 10 to 15 or from 15 to 20 mg/kg resulted in a significantly prolonged total recovery time.
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Some Aspects of Short Term Thiopentone Sodium Anaesthesia With or Without Selected Pre-Anaesthetic Medications in Goat Kids
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