Pharmacology of Plants of Putative Hypoglycaemic Activities

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Date
2015-06-23
Authors
Einas Sayed Ahmed Ibrahim, Ibrahim
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Publisher
UOFK
Abstract
The hypoglycaemic effects of three plants traditionally used in the Sudan for treatment of diabetes mellitus were studied. These plants were Citrullus colocynthis, Striga hermonthica and Bauhinia rufescens. Pharmacological studies on the water extract (decoction) of S. hermonthica and ethanolic extract of leaves of B. rufescens were also carried out. The powdered seeds of C. colocynthis suspended in gum acacia 25 (w/v) was orally administered to glucose loaded rats in three different doses of 4, 40 and 2000 mg/kg body weight. No decrease in the plasma glucose levels was observed. For S. hermonthica (whole plant), oral administration of the water extract in a dose of 2 g/kg, ethanolic extract (75%) in a dose of 1 g/kg, chloroformic extract in a dose of 200 mg/kg and petroleum ether extract in a dose of 1 g/kg body weight did not induce any decrease in plasma glucose levels. For the leaves of B. rufescens, oral administration of water extract (decoction and maceration) in a dose of 1 g/kg, ethanolic (95%) in doses 500, 2000 mg/kg, ethanolic (75%) in doses 200, 1000 mg/kg and dichloromethane extract in a dose of 1 g/kg body weight did not cause any decrease in plasma glucose levels of treated rats. Only petroleum ether extract of leaves of B. rufescens in doses of 1 or 2 g/kg body weight showed significant non-dose dependent hypoglycaemic effects. Pharmacological studies on water extract of S. hermonthica showed that it has serotonin-like activity and this activity was partially blocked by cypropheptadine. Pharmacological studies on ethanolic (95%) extract of B. rufescens leaves showed that it possesses noradrenaline-like activity which was completely blocked by phentolamine.
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Pharmacology of Plants of Putative Hypoglycaemic Activities
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