Measurement of Some Biochemical Parameters Related to Infection with Plasmodium falciparum Malaria.

Abstract

This work was carried out in the Department of Biochemistry, Faculty of Veterinary medicine, University of Khartoum. Samples were collected from El Duiem province. Forty seven individuals were selected for this study; all were a adults in El Diuem province. Their age ranged between 20-40 years old. Thirty six of them are malarial patients (19 are males and 17 are females). The other thirty eight individuals were apparently healthy and used as control groups as (18 males and 20 females).The blood samples were taken from the cephalic vein for investigation of malaria parasite, plasma proteins and total IgG. Total IgG was measured using Radioimmunoassay method (RIA). The effect of sex and degree of parasitemia was considered for all parameters studied. The result obtained revealed that, total protein and albumin were significantly (p<0.05) lower in malaria patients compared to healthy individuals whereas total globulin and IgG appeared significantly increased during infection with P. falciparum malaria. The result obtained showed that, the total proteins , total globulins and IgG were significantly (p< 0.05) higher in one cross patients compared to the control, and showed significantly (p<0.05) lower values in two cross patients compared to the control, whereas the albumin fraction sowed slightly lower values in patients compared to the control.