Epidermal Growth Factor Receptor Intron 1 CA repeat Polymorphism in Sudanese Breast Cancer Patients
Epidermal Growth Factor Receptor Intron 1 CA repeat Polymorphism in Sudanese Breast Cancer Patients
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Date
2008-08
Authors
Ahmed, Sami
El-Tayeb, Muntasir
Journal Title
Journal ISSN
Volume Title
Publisher
University of Khartoum
Abstract
Epidermal Growth Factor Receptor is one of the erbB family of Receptor
Tyrosine Kinases (RTKs). A highly polymorphic microsatellite in intron 1 of the gene
was found to affect the expression of the gene. Individuals with shorter repeats were
found to have higher expression levels of the protein, and therefore benefit more from
anti-EGFR drugs.
In the present study 11 breast cancer patients and 12 healthy volunteers from the
Sudanese population were genotyped using polymerase chain reaction and
polyacrylamide gel electrophoresis.
Two alleles were found: a short allele with a frequency of 0.591 in breast cancer
patients and 0.083 in healthy volunteers, and along allele with a frequency of 0.409 in
breast cancer patients and 0.917 in healthy volunteers.
It can be concluded that the length of this CA-SSR may have a major role in
carcinogenisis in Sudanese breast cancer patients.
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Keywords
Breast Cancer in Sudan,The Epidermal Growth Factor Receptor,EGFR Signaling,Ethnicity,Polyacryclamide gel electrophoresis