HISTOPATHOLOGICAl CHARACTERISTICS OF THYROID TUMORS AMONG SUDANESE PATIENTS
HISTOPATHOLOGICAl CHARACTERISTICS OF THYROID TUMORS AMONG SUDANESE PATIENTS
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Date
2015-04-12
Authors
Mohamed, Saifaldin
Journal Title
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Publisher
UOFK
Abstract
This is a descriptive retrospective study about thyroid tumors in Sudanese patients. It
was carried out in the period from January 2006 to December 2008.The study was
conducted in the three main histopathology laboratories in Sudan, the National Health
Laboratory (NHL), Radiation and Isotope Center-Khartoum (RICK), and Soba
University Hospital (SOH).
The study aimed at determining the histopathological pattern of thyroid tumors and to
show the distribution of age, sex, risk factors, origin, ethnic groups, and clinical
presentation of these tumors.
Ninety seven (97) cases of thyroid tumors were analyzed in the study. The age of the
patients ranged between 12 to 80 years with a mean of 37.54+14.72 years. The
commonest age group was 30 to <40 years (27.8%).Females constituted 86.6% of the
patients, with a male to female ratio of 1: 6.5.
The study revealed that the prevalence of follicular adenoma in goitrous patients was
7.5%, and that of malignant thyroid tumors was 2.9%. Follicular adenoma was the
most common thyroid tumor constituting 72.2% of all thyroid tumors. Papillary
carcinoma came next (12.4%) then follicular carcinoma (9.3%). Medullary carcinoma
(3.1%) and anaplastic carcinoma (3.1%).
Follicular adenoma occurred most commonly in adults aged 20 to <50 years
(78.6%).The male to female ratio was 1: 7.75.
The age group > 20 to < 50 was the commonest age group affected by malignant
thyroid tumors (55.5%). No malignant thyroid tumors was diagnosed in age group
<11 years. As a conclusion, the study showed that thyroid cancers occurred most
commonly in young and middle aged adults and was rare in children.
Regarding the grading of thyroid malignancies 52% of thyroid cancers in the study
were of low grade malignancy, 37% were intermediate grade malignancy and 11.1%
were of high grade malignancy.
The study revealed that the percentage of malignancy diagnosed by FNABs was
35.7%. Benign category constituted 50% and the indeterminate/suspicious category
constituted 14.3%.
The evaluation of thyroid tumors according to geographic regions, among ethnic
groups and the correlation with risk factors could not be obtained as these data were
not documented in the request forms. This entails urgent intervention otherwise
thyroid tumor epidemiology will continue to be deficient.
When all the findings in the study are compared together, it can be concluded that the
histological pattern of thyroid tumors, the sex and age distributions in the study tend
to correspond with studies in other countries.
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Keywords
HISTOPATHOLOGICAl, CHARACTERISTICS, THYROID, TUMORS