Genetic Association of The Fas (Rs1800682) And Fas Legend (Rs763110) Gene Polymorphisms With Acute And Chronic Allograft Rejection Among Sudanese Patients

Abstract

Introduction: Graft loss in renal transplant recipients remains significant, with consequential high morbidity, mortality and costs. Both allo-immune and non-immune factors often interact causing damage to the kidney allograft. FAS/FASL system has an important role in progressive renal disease and rejection. Objective: A panel of acute and chronic renal transplant rejection patients were used to investigate the distribution of FAS-670 A/G and FASL-843 C/T gene polymorphisms among ESRD Sudanese patients using PCR-RFLP method. Results: Hypertension was found to be the major risk factor among both rejection groups. The A-carriers (AA+GA) were more frequent among both rejection groups (77.8%). Patients carrying A-Allele were more reported among acute rejection patients (83.8%) suggesting correlation of A- allele carriers with acute rejection. FASL gene mutant T allele was quite frequent among both rejection groups (~43%); indicating possible role in the rejection of allograft. Conclusion: Although differences in genotype frequencies of both FAS-670A/G and FASL–843C/T were not statistically significant between patients with acute and chronic transplantation rejection patients (P>0.05 for all). The role of FAS/FASL interaction in allograft rejection is still a matter of ponder.