Genetic Association of The Fas (Rs1800682) And Fas Legend (Rs763110) Gene Polymorphisms With Acute And Chronic Allograft Rejection Among Sudanese Patients
Genetic Association of The Fas (Rs1800682) And Fas Legend (Rs763110) Gene Polymorphisms With Acute And Chronic Allograft Rejection Among Sudanese Patients
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Date
2015-11-18
Authors
El Mutalib, Ihsan Taj Elsir Abd
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Publisher
University of Khartoum
Abstract
Introduction: Graft loss in renal transplant recipients remains significant, with consequential high morbidity, mortality and costs. Both allo-immune and non-immune factors often interact causing damage to the kidney allograft. FAS/FASL system has an important role in progressive renal disease and rejection. Objective: A panel of acute and chronic renal transplant rejection patients were used to investigate the distribution of FAS-670 A/G and FASL-843 C/T gene polymorphisms among ESRD Sudanese patients using PCR-RFLP method. Results: Hypertension was found to be the major risk factor among both rejection groups. The A-carriers (AA+GA) were more frequent among both rejection groups (77.8%). Patients carrying A-Allele were more reported among acute rejection patients (83.8%) suggesting correlation of A- allele carriers with acute rejection. FASL gene mutant T allele was quite frequent among both rejection groups (~43%); indicating possible role in the rejection of allograft. Conclusion: Although differences in genotype frequencies of both FAS-670A/G and FASL–843C/T were not statistically significant between patients with acute and chronic transplantation rejection patients (P>0.05 for all). The role of FAS/FASL interaction in allograft rejection is still a matter of ponder.
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Keywords
Sudanese Patients,
Chronic,
Genetic Association