MOLECULAR ANALYSIS OF CHEMOKINE RECEPTOR TYPE 5 (CCR5) CODING REGIONS IN HIV-1\AIDS SUDANESE PATIENTS

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Date
2009
Authors
Ismaiel, Marwa
El-Tayeb, Muntaser
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Publisher
uofk
Abstract
Chemokine receptors are a subclass of seven transmembrane Gprotein coupled receptors, a number of which act as co-receptors with CD4 for HIV1 infection, different polymorphisms within chemokine receptor genes were found to associate with susceptibility to HIV-1 infection and its progression. Analysis of CCR5 for genetic variants in different populations has identified several rare alleles, however most detected polymorphisms in the CC- chemokine receptor 5 (CCR5) gene were specific to different populations.
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Keywords
Splice Site Prediction,CCR5C,Genotyping
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