MOLECULAR ANALYSIS OF CHEMOKINE RECEPTOR TYPE 5 (CCR5) CODING REGIONS IN HIV-1\AIDS SUDANESE PATIENTS

Abstract

Chemokine receptors are a subclass of seven transmembrane Gprotein coupled receptors, a number of which act as co-receptors with CD4 for HIV1 infection, different polymorphisms within chemokine receptor genes were found to associate with susceptibility to HIV-1 infection and its progression. Analysis of CCR5 for genetic variants in different populations has identified several rare alleles, however most detected polymorphisms in the CC- chemokine receptor 5 (CCR5) gene were specific to different populations.