The Effect of Cinnamomum.Verum (Elgerfa)on Glucose Tolerance and Plasma Parameter Profile in Alloxan Induced Diabetic Rats

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Mustafa, Rania
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University of Khartoum
Cinnamon is used in many countries for treatmentof bacterial and fungal diseases, cold influenza and asantioxidant agent .Recently, people discovered that Cinnamomum cassiainduce hypoglycemia and improving lipid metabolism in patient with type 2 diabetes mellitus. This study tested the antidiabetic and hypoglycemic effect of the Cinnamomum verum which available in Sudan. The effect of the plant on the plasma glucose, total protein, albumin, bilrubin, cholestrol, low density lipoprotein- cholestrol, high density lipoprotein- cholestrol, triglyceride and liver enzymes (alanine amino transferase and aspartate amino transferase) were evaluated in diabetic and normal rats. Wistar albino rats were used in the present work .The diabetes was induced by injection of alloxan monohydrate at dose of 150 mg/kg body weight. The experiment extended over three weeks. Rats were divided into four groups each group consisted of 5 rats: GroupAwas control group and contained normal rats, Group B contained normalrats given orally Cinnamon bark powder suspended in distilled waterat dose of 1g/ kg body weight for 21 days, Group C contained diabetic ratsand GroupD contained diabetic rats given orally Cinnamon bark powder mixed with distilled water at dose of 1g/ kg body weight for 21 days to examine the C. verum effect on diabetic rats. The plasma glucose level of all rats were measured on day zero and day 3 after overnight fasting toestimate blood glucose level for checking whether the diabeteswas induced by alloxan injection or not. On day 21 st blood was collected from eachrats after fasting for 18 hours to determine the level of plasma glucose at 0 h, then rats were injected with 50% glucose at dose of 2g /kg body weight and blood was collected to monitor plasma glucose level at 1 h and 2 h after glucose was given. On day 22 nd rats were sacrificed and the blood was collected to xii estimate the biochemical parameters. Glucose tolerance test carried out inthis experiment showed that, daily oral administration of C. verumfor 21 days lowered significantly(P≤0.05) the plasma glucose level of diabetic rats at 0, 1and 2 h after overnight fasting compared to diabetic rat’s not given C. verum.Also at 0 , 1 , 2h after overnight fasting, it was noticed that there was no significant difference in glucose level between normal control rats and normal rats given orally C. verum. The oral administration of C. verumhad no significant effect on plasma bilrubin, albumin, low density lipoprotein - cholestrol, alanine amino transferase concentration and body weight in both normal and diabetic rats. Alsoit was noticed that the oral administration of C. verumdecreased significantly plasma cholestrol, high density lipoprotein-cholestrol, and total protein in diabetic rats when compared to normal control rats. But it decreased numerically plasma triglyceride in diabetic rats when compared to normal control rats and increased numerically plasma AST in diabetic rats when compared to normal control rats. This experiment showed that C. verumcould be used to lower hyperglycemia in type1 diabetic patients, and it is promising antidiabetic agent