EFFICACY OF SOME ANTIMALARIAL DRUGS IN TREATMENT OF Eimeria tenellaIN CHICKENS

Abstract

This research was carried out to study the efficacy of three synthetic anti-malarial drugs (primaquine at level 31.2, 125 and 250 ppm, fancedar (86.625mg) and artesunate(33mg) and one anticoccidial medication (amprolium 60g/100 Liter) asa reference. The drugs were administered in drinking water to treat Eimeria tenellain chickens. Atotal of 280 3- week old male Hisex strain chicks were divided in to 14 even groups , control naive (uninfected unmedicated group), (infected unmedicated group) ,6 groups of infected treated by antimalarial medications (primaquine31.2, 125 and 250 ppm, fancedar 86.625mg and artesunate 33mg) and anti-coccidial drug (amprolium 60g/100 Liter) and 6 groups of control uninfected medicated, as prophylactic additives and to test their impact on the chicks behaviour and to test the toxicity. Infection was carried out by inoculation of sporulated oocyst 1×10 4 in the chicks' crops. Treatment started on the third day of infection. Results indiceted that utilization of primaquine level 125 ppm demonstrated heavier weight gain. All the sick chicks recovered from the disease and none of them died and no oocysts were recovered in the faeces. During treatment of birds withprimaquine level 31.2 ppm, feed intake was lower among birds. All the sick chicks recovered from the disease and none of them died and no oocysts were recovered in the faeces. During treatment of chicks with primaquine level 250 ppm, secured the lowest food intake withthe highest mortality rate. Among this group the lowest value of mean cell value (MCV) and toxic ix symptoms were recorded. The administration of artesunate revealed a higher food intake. All the sick chicks recovered from the disease and none of them died rate and no oocystswere recovered in the faeces and the highest values of MCV were recorded. Administration of fancedar recorded a higher food intake with all the sick chicks recovered from the disease and non of them died, and no oocysts were recovered in the faeces with administration of anticoccidial (amprolium), all of the sick chicks recovered from the disease and non of them died, and exerted the highest values of MCV. It is concluded that antimalarial drugs (primaquine 31.2, 125 and 250 ppm artesunate 33 mg, fancedar 86.625 mg) for treatment of Eimeria tenellawas effective compared with anticoccidial drug (amprolium). However, the high level of pimaquine 250 ppm as prophylactic additive was toxic.