Treatment related complications in Sudanese haemophilic patients
Treatment related complications in Sudanese haemophilic patients
No Thumbnail Available
Date
2015-03-31
Authors
Mohamed, Abdelrahman
Journal Title
Journal ISSN
Volume Title
Publisher
UOFK
Abstract
Because of the increased use of the various types of factor
replacement therapy in haemophilic patients, this study was conducted to
determine the prevalence of some treatment related complications
(development of factor inhibitors, HIV, HBV and HCV infection), and the
possible underlying factors that increase the risk of their occurrence
This study was a descriptive cross-sectional hospital based study
carried out in the period between the 25th of August and 25th of December
2003 in which 59 haemophilic patients were included. Their ages ranged
between 1-42 years, 39% of them were children. 91% of them were
suffering from haemophilia A, 6.8% were cases of haemophilia B and only
one patient was a case of haemophilia C.
52% had developed hypersensitivity reaction to one or more forms
of treatment. The majority showing hypersensitivity to fresh frozen plasma.
The prevalence of development of factor inhibitors was found to be
29% all of them being factor VIII inhibitors. The prevalence of HIV was
3%, that of HBV was also 3% while HCV infection occurred in 11%.
A conclusion was drawn that the prevalence of inhibitors was high,
children and young adults were affected more, and receiving factor
concentrate treatment was a frequent associated factor. On the other hand
12
viral transmission had low prevalence, affected adults more than children
and is slightly more associated with frequent use of fresh frozen plasma
treatment.
Establishment of a routine screening programme for detection of
these complications, establishment of vaccination programme and proper
screening of blood products were recommended.
Description
Keywords
haemophilic,blood vessel endothelia,Cause of death,Female carriers