Synthesis of Some Hydrolases Models and their Inhibitions

Abstract

Enzymes containing two metal ions in close proximity (3-5 ? ) with bridging ligand(s) in the active site, known as a dinuclear metalloenzymes, catalyze a wide range of chemical reactions in nature, including hydrolytic cleavage the C-N bond of urea and guanidine, the N-terminal peptide bond of proteins, and the hydrolysis of phosphates esters. It is well documented that hydroxamic acids reversibly inhibit a number of these hydrolases reactions of metalloenzymes