Activity test ofCommiphora myrrhto Helicobacter pylori compared with commonly used Antimicrobial Agents

Abstract

The present study aimed to isolate Helicobacter pyloriand conduct the susceptibility tests to Commiphora myrrhin comparison with widely used antibiotics. The study samples were collected from Sudanese patients who were suffering from peptic disease during the period September 2006 to November 2007 in Ibn Sina T. Hospital. The study population was 52 females and 48 males their ages ranged between 19 and 70 years. It was observed that high prevalence ofHelicobacter pylori infection in old ages . The study included 32 manual worker, 31 house wives and 15 students , 6 farmers and 16 other jobs (Doctors ,Employers ,Engineers and Teachers). Helicobacter pyloriwas isolated in sixty of the total of one hundred specimen collected. The sensitivity tests were done against Amoxicillin, tetracycline ,Metronidazole and Clarithromycin by disk diffusion method and Commiphora myrrh extraction by agar dilution in four dilution 1/20,1/40,1//80 and 1/160. Itwas found that 71% of isolates were sensitive to Amoxicillin, 61.7%Tetracycline ,38.3% to Metronedazole and35% to Clarithromicin ,In Commiphora myrrh dilution one (1/20)which highist sensitivity rate 100% . Dilution two(1/40) 90% .50% for dilution three(1/80). And 20 % for dilution four (1/160) . That means that Amoxicillin is the best choice and the MIC of Commiphora myrrh extraction is 1/20 and Commiphora myrrh may be examined as an alternative treatment against Helicobacter pylori