The Immunological Characterization of Hyper-reactive Malarial Splenomegaly Syndrome (HMS) in Sudan
The Immunological Characterization of Hyper-reactive Malarial Splenomegaly Syndrome (HMS) in Sudan
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Date
2005
Authors
Abdel Hady, Tayseer
Mohammed, Ibrahim
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Journal ISSN
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Publisher
University of Khartoum
Abstract
The present work aied at studying the immunological characterization of
Hyper-reactive Malarial Splenomegaly Syndrome in Sudan. A hospital
based study was carried out in the period between January 2000 and
December 2004 in Ommdurman Tropical Diseases Hospital. HMS patients
were interviewed and they had many investigations to differentiate HMS
from other diseases which cause splenomegaly. Thirty one samples were
collected to determine the molecular characterizations of the malaria parasite
and to determine immunological responses to malaria candidate
Circumsporozoite protein (CSP), also to measure the level of total IgM in
Sudanese HMS patients' sera and to measure their cytokines (IL-10 & IFNγ).
Males were found more affected by the disease (61%male - 38%female).
The most common age group affected was between eleven and thirty two.
Microscopic detection has shown that only one HMS patient had positive
blood film for P. falciparum. No other malaria parasite species were
detected. Using PCR the result was in agreement with the microscopic
examinations P. falciparum parasite was detected in one patient, and no
infection with P. vivax was detected.
IgG antibodies to malaria specific antigen (CSP) were measured in 31 sera
samples, IgG titers were found to be high but not significant in HMS
patients compared with positive malaria control, whereas positive malaria
controls showed significantly higher titers compared with European negative
malaria control (P=0.005).
Description
Keywords
Malaria in Sudan