Cavanagh, DAVID R.DOBAN˜ O, CARLOTAELHASSAN, IBRAHIM M.MARSH, KEVINElhassan, Ahmed M.HVIID, LARSKhalil, E. At Tahir G.Theander, Thor G.Arnot, David E.Mcbride, Jana S.Ibrahim M ElhassanDepartment of Molecular Biology2015-11-152015-11-152015-11-152015http://khartoumspace.uofk.edu/123456789/170966 PagesComparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-119 are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.enPlasmodium falciparumSurface ProteinHumanDifferential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparumPublication