University of Khartoum

The 5q31 Region in two African populations as a Facet of Natural Selection by Infectious Diseases

Show simple item record Ibrahim, Muntaser E. Mohamed, Hiba S.
dc.contributor.editor en_US
dc.contributor.other Molecular Biology en_US 2013-02 2015-11-15T11:04:52Z 2015-11-15T11:04:52Z 2015-11-15 2015
dc.description.abstract Cases of extreme natural selection could lead either to rapid fixation or extinction of alleles depending on the population structure and size. It may also manifest in excess of heterozygosity and the locus concerned will be displaying such drastic features of allele change. We suspect the 5q31 in chromosome 5 to mirror situation of such extreme natural selection particularly that the region encompasses genes of type 2 cytokine known to associate with a number of infectious and non infectious diseases. We typed two sets of single nucleotide polymorphisms (SNPS) in two populations: an initial limited set of only 4 SNPS within the genes of IL 4, IL 13, IL 5 and IL 9 in 108 unrelated individuals and a replicating set of 14 SNP in 924 individuals from the same populations with disregard to relatedness. The results suggest the 5q31 area to be under intense selective pressure as indicated by marked heterozygosity independent of Linkage Disequilibrium (LD); difference in heterozygosity, allele, and haplotype frequencies between gener ations and departure from Hardy–Weinberg expectations (DHWE). The study area is endemic for several in fectious diseases including malaria and visceral leishmaniasis (VL). Malaria caused by Plasmodium falci parum, however, occurs mostly with mild clinical symptoms in all ages, which makes it unlikely to account for these indices. The strong selection signals seems to emanate from recent outbreaks of VL which affected both populations to varying extent. en_US
dc.language.iso en en_US
dc.publisher UOFK en_US
dc.subject 5q31 region en_US
dc.subject African populations en_US
dc.subject natural selection en_US
dc.subject infectious diseases en_US
dc.title The 5q31 Region in two African populations as a Facet of Natural Selection by Infectious Diseases en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US

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