University of Khartoum

Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis—A meta-analysis

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dc.contributor.author Noazin, Sassan
dc.contributor.author Khamesipour, Ali
dc.contributor.author Moulton, Lawrence H.
dc.date 2009
dc.date.accessioned 2015-11-26T06:14:18Z
dc.date.available 2015-11-26T06:14:18Z
dc.date.issued 2015-11-26
dc.date.submitted 2015
dc.identifier.uri http://khartoumspace.uofk.edu/123456789/17299
dc.description.abstract Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in some of the controlled trials conducted with “first-generation” whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published or unpublished randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis of qualified trials was conducted to evaluate whether there was some evidence of protection revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis en_US
dc.publisher university of khartoum en_US
dc.subject Leishmaniasis vaccine Meta-analysis Clinical trial en_US
dc.title Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis—A meta-analysis en_US
dc.type Publication en_US
dc.Faculty Endemic Diseases en_US


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