University of Khartoum

The Aetiology of Early-Onset Parkinson’s Disease (EOPD): Molecules and Processes A Narrative Review

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dc.contributor.author Mohammed, Hiba Rahmet-Allah Ahmed
dc.date.accessioned 2021-05-17T07:30:59Z
dc.date.available 2021-05-17T07:30:59Z
dc.date.issued 2016
dc.identifier.uri https://khartoumspace.uofk.edu123456789/27948
dc.description.abstract Parkinson's Disease (PD) is a progressive neurodegenerative brain disorder that manifests clinically with motor abnormalities, autonomic disturbances, and psychiatric and cognitive impairments. A rare subset of PD is familial/ inherited with identified monogenetic Mendelian forms. Most cases manifest at an early age- thus termed Early-onset (or Young-onset) PD (EOPD). EOPD has milder and slower clinical progression, making it a candidate for individualized therapeutic interventions, and moreover, a promising model for clarification of molecular pathways that underline all PD variants and may be other neurodegenerative conditions. This review looked into publications on the causes and pathological molecular processes of EOPD over the past decade in order to accumulate evidence that can direct further research in the disease aetiology and possible therapeutic approaches. Many genes have been implicated as causes for EOPD, but the molecular processes of the disease pathogenesis are far from clear. The role of exogenous environmental factors in the disease process has not been studies extensively, and this remains an area for wider research. A major challenge facing future studies on the aetiology of PD is the construction of authentic cellular or animal models replicating human pathogenesis to ensure reliable results of investigations for pathway clarification and therapeutic trials. en_US
dc.language.iso en en_US
dc.publisher University of Khartoum en_US
dc.subject The Aetiology;Early-Onset Parkinson’s Disease (EOPD); Molecules ; Processes; A Narrative Review en_US
dc.title The Aetiology of Early-Onset Parkinson’s Disease (EOPD): Molecules and Processes A Narrative Review en_US
dc.type Thesis en_US


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