The Genetic Structure and History of Africans and African Americans

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dc.FacultyEndemic Diseasesen_US
dc.contributor.authorIbrahim, Muntaser E.
dc.contributor.authorAwomoyi, Agnes
dc.contributor.authorTishkoff, Sarah A.
dc.contributor.editoren_US
dc.contributor.otherMolecular Biologyen_US
dc.date2009-06
dc.date.accessioned2015-11-15T10:43:27Z
dc.date.available2015-11-15T10:43:27Z
dc.date.issued2015-11-15
dc.date.submitted2015
dc.description.abstractAfrica is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (~71%), European (~13%), and other African (~8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies.en_US
dc.identifier.urihttp://khartoumspace.uofk.edu/123456789/17099
dc.language.isoenen_US
dc.publisherUOFKen_US
dc.subjectGenetic Structureen_US
dc.subjectHistoryen_US
dc.subjectAfricansen_US
dc.subjectAfrican Americansen_US
dc.titleThe Genetic Structure and History of Africans and African Americansen_US
dc.typePublicationen_US

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