Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis—A meta-analysis
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Date
2015-11-26
Authors
Noazin, Sassan
Khamesipour, Ali
Moulton, Lawrence H.
Journal Title
Journal ISSN
Volume Title
Publisher
university of khartoum
Abstract
Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania
infections has not been developed. Although some indication of protection was observed in some of
the controlled trials conducted with “first-generation” whole, inactivated Leishmania parasite vaccines,
convincing evidence of protection was lacking. After reviewing all previously published or unpublished
randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis
of qualified trials was conducted to evaluate whether there was some evidence of protection revealed
by considering the results of all trials together. The findings indicate that the whole-parasite vaccine
candidates tested do not confer significant protection against human leishmaniasis
Description
Keywords
Leishmaniasis vaccine Meta-analysis Clinical trial