IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan
| dc.Faculty | Endemic Diseases | en_US |
| dc.contributor.author | Ibrahim, Muntaser E. | |
| dc.contributor.author | Salih, Mohamed | |
| dc.contributor.author | Khalil, Eltahir Awad G. | |
| dc.contributor.author | Mohamed, Hiba S. | |
| dc.contributor.author | etal. | |
| dc.contributor.editor | en_US | |
| dc.contributor.other | Molecular Biology | en_US |
| dc.date | 2007-02 | |
| dc.date.accessioned | 2015-11-12T10:38:34Z | |
| dc.date.available | 2015-11-12T10:38:34Z | |
| dc.date.issued | 2015-11-12 | |
| dc.date.submitted | 2015 | |
| dc.description.abstract | Post kala-azar dermal leishmanaisis (PKDL) in Sudan is associated with elevated interferon-γ. To study interferon-γ pathways in PKDL, we genotyped 80 trios from the Masalit ethnic group for polymorphisms at −470 ins/delTT, -270T/C, -56T/C and +95T/C in IFNGR1, and at −179G/A and +874T/A in IFNG. No associations occurred at IFNG. Global association with haplotypes comprising all 4 markers at IFNGR1 (χ2 10df = 21.97, P=0.015) was observed, associated with a significant (χ2 1df=4.54, P=0.033) bias in transmission of the haplotype insTT T T T, and less (χ2 1df=5.59, P=0.018) than expected transmission of insTT C C C. When compared with data on malaria associations from The Gambia, the results suggest a complex pattern of haplotypic variation at the IFNGR1 promoter locus associated with different infectious disease in African populations that reflect the complex roles of IFN-γ in parasite killing versus inflammation and pathogenesis. | en_US |
| dc.identifier.uri | http://khartoumspace.uofk.edu/123456789/17032 | |
| dc.language.iso | en | en_US |
| dc.publisher | UOFK | en_US |
| dc.subject | PKDL; leishmaniasis; association; IFNGR1 | en_US |
| dc.title | IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan | en_US |
| dc.type | Publication | en_US |