A Longitudinal Study of Type-Specific Antibody Responses to Plasmodium falciparum Merozoite Surface Protein-1 in an Area of Unstable Malaria in Sudan

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dc.FacultyEndemic Diseasesen_US
dc.contributor.authorCavanagh, David R.
dc.contributor.authorElhassan, Ibrahim M.
dc.contributor.authorRoper, Cally
dc.contributor.editorIbrahim M Elhassanen_US
dc.date1998
dc.date.accessioned2015-11-16T09:46:14Z
dc.date.available2015-11-16T09:46:14Z
dc.date.issued2015-11-16
dc.date.submitted2015
dc.description.abstractMerozoite surface protein-1 (MSP-1) of Plasmodium falciparum is a malaria vaccine candidate Ag. Immunity to MSP-1 has been implicated in protection against infection in animal models. However, MSP-1 is a polymorphic protein and its immune recognition by humans following infection is not well understood. We have compared the immunogenicity of conserved and polymorphic regions of MSP-1, the specificity of Ab responses to a polymorphic region of the Ag, and the duration of these responses in Sudanese villagers intermittently exposed to P. falciparum infections. Recombinant Ags representing the conserved N terminus (Block 1), the conserved C terminus, and the three main types of the major polymorphic region (Block 2) of MSP-1 were used to determine the specificity and longitudinal patterns of IgG Ab responses to MSP-1 in individuals. Abs from 52 donors were assessed before, during, and after malaria transmission seasons for 4 yr. Ags from the Block 1 region were rarely recognized by any donor. Responses to the C-terminal Ag occurred in the majority of acutely infected individuals and thus were a reliable indicator of recent clinical infection. Ags from the polymorphic Block 2 region of MSP-1 were recognized by many, although not all individuals after clinical malaria infections. Responses to Block 2 were type specific and correlated with PCR typing of parasites present at the time of infection. Responses to all of these Ags declined within a few months of drug treatment and parasite clearance, indicating that naturally induced human Ab responses to MSP-1 are short lived. The Journal of Immunology, 1998, 161: 347–359.en_US
dc.identifier.urihttp://khartoumspace.uofk.edu/123456789/17133
dc.language.isoenen_US
dc.publisherThe Journal Of Immunologyen_US
dc.subjectSudanen_US
dc.subjectProteinen_US
dc.subjectMalariaen_US
dc.titleA Longitudinal Study of Type-Specific Antibody Responses to Plasmodium falciparum Merozoite Surface Protein-1 in an Area of Unstable Malaria in Sudanen_US
dc.typePublicationen_US

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