Frequencies of BCR-ABL1 Fusion Transcripts among Sudanese Chronic Myeloid Leukemia Patients
| dc.Faculty | Endemic Diseases | en_US |
| dc.contributor.author | Ibrahim, Muntaser E. | |
| dc.contributor.author | Osman, Emad Aldin Ibrahim | |
| dc.contributor.author | Fadl-Elmula, Imad Mohamed | |
| dc.contributor.author | etal. | |
| dc.contributor.editor | en_US | |
| dc.contributor.other | Molecular Biology | en_US |
| dc.date | 2010-04 | |
| dc.date.accessioned | 2015-11-16T10:10:40Z | |
| dc.date.available | 2015-11-16T10:10:40Z | |
| dc.date.issued | 2015-11-16 | |
| dc.date.submitted | 2015 | |
| dc.description.abstract | The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. In this study we report the frequencies of BCR-ABL1 fusion transcript variants studied in 43 CML patients from Sudan. The study includes 46 Sudanese patients, three of which negative for the BCR-ABL1 fusion transcript. More than half of 43 positive patients showed b2a2 fusion transcript (53.5%), while (41.9%) showed b3a2 transcript and the remaining (4.6%) coexpression of b3a2/ b2a2 and b3a2/b2a2/e19a2. We detected neither coexpression of p210/p190 nor e1a2 alone. Male patients showed a tendency to express b2a2, while female tende to express b3a2 (p = 0.017). Moreover, a single nucleotide polymorphism was detected in BCR exon 13 in one out of four patients and this patient showed only b2a2 expression. In conclusion, we observed a significant correlation between sex and type of BCR-ABL1 transcript, an observation that deserves further investigation. | en_US |
| dc.identifier.uri | http://khartoumspace.uofk.edu/123456789/17141 | |
| dc.language.iso | en | en_US |
| dc.publisher | UOFK | en_US |
| dc.subject | BCR-ABL, chronic myeloid leukemia, Ph chromosome, Sudanese, RT-PCR | en_US |
| dc.title | Frequencies of BCR-ABL1 Fusion Transcripts among Sudanese Chronic Myeloid Leukemia Patients | en_US |
| dc.type | Publication | en_US |