Leishmania Resistant to Sodium Stibogluconate: drug-Associated Macrophage-Dependent Killing
| dc.Faculty | Endemic Diseases | en_US |
| dc.contributor.author | Elhassan, Ahmed M. | |
| dc.contributor.author | Ibrahim, Muntaser E. | |
| dc.date | 1994 | |
| dc.date.accessioned | 2015-11-29T09:44:17Z | |
| dc.date.available | 2015-11-29T09:44:17Z | |
| dc.date.issued | 2015-11-29 | |
| dc.date.submitted | 2015 | |
| dc.description.abstract | A total of 17Leishmania isolates, 6 of them isolated from antimony-resistant patients, were collected in the Sudan and tested for their sensitivity to sodium stibogluconate (Pentostam) as promastigotes. Six of those isolates were tested as amastigotes infecting a murine macrophage cell line. The results indicated that the conventional promastigote screening assay did not correlate with the clinical picture, whereas the amastigote/macrophage system produced results that pertained to the in vivo responses to the drug. A laboratory-generated resistant strain ofL. major was adapted to grow at a high concentration of Pentostam (1000 μg/ml) as promastigotes but was quite sensitive to the drug at much lower concentrations in the amastigote/(macrophage system (20μg/ml), thus suggesting that Pentostam's inhibitory action is mediated through the macrophage rather than through a direct toxic effect exerted on the parasite | en_US |
| dc.identifier.uri | http://khartoumspace.uofk.edu/123456789/17339 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.subject | killing | en_US |
| dc.subject | sodium | en_US |
| dc.subject | Leishmania | en_US |
| dc.title | Leishmania Resistant to Sodium Stibogluconate: drug-Associated Macrophage-Dependent Killing | en_US |
| dc.type | Publication | en_US |