Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum

Cavanagh, DAVID R.; DOBAN˜ O, CARLOTA; ELHASSAN, IBRAHIM M.; MARSH, KEVIN; Elhassan, Ahmed M.; HVIID, LARS; Khalil, E. At Tahir G.; Theander, Thor G.; Arnot, David E.; Mcbride, Jana S.

Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum

Date

2015-11-15

Authors

Cavanagh, DAVID R.

DOBAN˜ O, CARLOTA

ELHASSAN, IBRAHIM M.

MARSH, KEVIN

Elhassan, Ahmed M.

HVIID, LARS

Khalil, E. At Tahir G.

Theander, Thor G.

Arnot, David E.

Mcbride, Jana S.

Publisher

University of Khartoum

Abstract

Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-119 are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.