Diversity among Leishmania Isolates from the Sudan: Isoenzyme Homogeneity of L. donovani Versus Heterogeneity of L. major

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Date

2015-11-29

Authors

Elhassan, Ahmed M.

Journal Title

Journal ISSN

Volume Title

Publisher

Oxford Journals

Abstract

Leishmania isolates from patients in the Sudan suffering from either visceral or cutaneous leishmaniasis were characterized using a battery of 12 enzymes. Aspartate aminotransferase separated the L. donovani isolates into 2 distinct zymodemes, but the overall results showed no significant geographical variation among L. donovani isolates. In contrast, the isolates of L. major were polymorphic, exhibiting differences in nucleoside hydrolase, 6-phosphogluconate dehydrogenase, superoxide dismutase, esterase, mannose phosphate isomerase, and aspartate aminotransferase, resulting in the description of 4 new enzymatic variants

Description

Keywords

zymodemes, Leishmania tropica, Leishmania donovani, leishmaniasis, Sudan

Citation

URI

http://khartoumspace.uofk.edu/123456789/17350

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Medical and Health
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