Chronic Plasmodium Falciparum Infections in an Area of Low intensity Malaria Transmission in the Sudan
| dc.Faculty | Endemic Diseases | en_US |
| dc.contributor.author | Hamad, A. A. | |
| dc.contributor.author | Elhassan, Ahmed M. | |
| dc.contributor.author | El Khalifa,A. A. | |
| dc.contributor.author | Ahmed,G. I. | |
| dc.contributor.author | Abdelrahim, S. A. | |
| dc.contributor.author | Theander, T. G. | |
| dc.contributor.author | Arnot,D. E. | |
| dc.date | 1999 | |
| dc.date.accessioned | 2015-11-19T06:28:27Z | |
| dc.date.available | 2015-11-19T06:28:27Z | |
| dc.date.issued | 2015-11-19 | |
| dc.date.submitted | 2015-11-19 | |
| dc.description.abstract | Chronic Plasmodium falciparum malaria infections in a Sudanese village, in an area of seasonal and unstable malaria transmission, were monitored and genetically characterized to study the in¯uence of persistent infection on the immunology and epidemiology of low endemicity malaria. During the October±December malaria season of 1996, 51 individuals out of a population of 420 had con®rmed and treated P. falciparum malaria in the village of Daraweesh in eastern Sudan. In a cross-sectional survey carried out in December 1996, an additional 6 individuals were found to harbour a microscopically negative but polymerase chain reaction (PCR)-positive P. falciparum infection. On 1 January 1997, a cohort of 43 individuals aged from 9 to 53, recruited from this group of recently malaria-infected individuals agreed to donate fortnightly blood samples for the next 9 months, the ®rst 6 of which constitute the long Sudanese dry season when transmission falls to undetectable levels. Each blood sample was tested for the presence of persistent malaria infection by microscopy and PCR. Parasite-positive samples were genotyped using PCR assays that detect allelic polymorphism at the MSP-1, MSP-2 and GLURP marker gene loci. Of 43 individuals 16 were found to maintain chronic P. falciparum infections which were continuously genetically characterized. | en_US |
| dc.identifier.uri | http://khartoumspace.uofk.edu/123456789/17235 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of Khartoum | en_US |
| dc.subject | Plasmodium falciparum | en_US |
| dc.subject | chronic infections | en_US |
| dc.subject | unstable malaria | en_US |
| dc.subject | premunition | en_US |
| dc.subject | Sudan | en_US |
| dc.title | Chronic Plasmodium Falciparum Infections in an Area of Low intensity Malaria Transmission in the Sudan | en_US |
| dc.type | Publication | en_US |