Y Chromosome Lineage- and Village-Specific Genes on Chromosomes 1p22 and 6q27 Control Visceral Leishmaniasis in Sudan
| dc.Faculty | Endemic Diseases | en_US |
| dc.contributor.author | Miller, E. Nancy | |
| dc.contributor.author | Mohamed, Hiba S. | |
| dc.contributor.author | Ibrahim, Muntaser E. | |
| dc.contributor.editor | Joanna Mountain, Stanford University, United States of America | en_US |
| dc.contributor.other | Molecular Biology | en_US |
| dc.date | 2007-05 | |
| dc.date.accessioned | 2015-11-12T12:37:37Z | |
| dc.date.available | 2015-11-12T12:37:37Z | |
| dc.date.issued | 2015-11-12 | |
| dc.date.submitted | 2015 | |
| dc.description.abstract | Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major susceptibility gene on Chromosome 22q12 in the Aringa ethnic group in Sudan. We now report a genome-wide scan using 69 families with 173 affected relatives from two villages occupied by the related Masalit ethnic group. A primary ten-centimorgan scan followed by refined mapping provided evidence for major loci at 1p22 (LOD score 5.65; nominal p¼1.72310 7; empirical p , 1310 5; kS¼ 5.1) and 6q27 (LOD score 3.74; nominal p ¼ 1.68 3 10 5; empirical p , 1 3 10 4; kS ¼ 2.3) that were Y chromosome– lineage and village-specific. Neither village supported a visceral leishmaniasis susceptibility gene on 22q12. The results suggest strong lineage-specific genes due to founder effect and consanguinity in these recently immigrant populations. These chance events in ethnically uniform African populations provide a powerful resource in the search for genes and mechanisms that regulate this complex disease. | en_US |
| dc.identifier.citation | Miller EN, Fadl M, Mohamed HS, Elzein A, Jamieson SE, et al. (2007) Y chromosome lineage- and village-specific genes on Chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan. PLoS Genet 3(5): e71. doi:10.1371/journal.pgen.0030071 | en_US |
| dc.identifier.uri | http://khartoumspace.uofk.edu/123456789/17061 | |
| dc.language.iso | en | en_US |
| dc.publisher | UOFK | en_US |
| dc.subject | Y Chromosome Lineage | en_US |
| dc.subject | Village-Specific Genes | en_US |
| dc.subject | Chromosomes 1p22 | en_US |
| dc.subject | 6q27 | en_US |
| dc.subject | Control Visceral Leishmaniasis | en_US |
| dc.subject | Sudan | en_US |
| dc.title | Y Chromosome Lineage- and Village-Specific Genes on Chromosomes 1p22 and 6q27 Control Visceral Leishmaniasis in Sudan | en_US |
| dc.type | Publication | en_US |