Antibody Reactivity to Conserved Linear Epitopes of Plasmodium Falciparum Erythrocyte Membrane Protein 1 (PfEMP1)

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dc.FacultyEndemic Diseasesen_US
dc.contributor.authorElhassan, Ibrahim M.
dc.contributor.authorElhassan, Ahmed M.
dc.contributor.author., etal
dc.date1998
dc.date.accessioned2015-11-30T07:43:27Z
dc.date.available2015-11-30T07:43:27Z
dc.date.issued2015-11-30
dc.date.submitted2015-11-30
dc.description.abstractThe Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of protein antigens are involved in adhesion of P. falciparum infected erythrocytes to the capillary endothelium of the host. Antibodies to variable regions of these proteins, measured by agglutination, correlates with clinical protection against falciparum malaria. In this study we investigated the occurrence of antibodies to conserved sequences of these very variable proteins in a population living in an area endemic for falciparum malaria. Using the ELISA method, we were able to measure an antibody response to three synthetic peptides derived from conserved regions of PfEMP1. The antibody responses to these peptides increased with age and were higher in individuals with asymptomatic P. falciparum infection compared to individuals presenting with fever attributable to falciparum malaria. This indicates that antibodies recognising the conserved regions of PfEMP1 arise upon exposure to the parasite, and that these may be involved in the development of protection against malaria. Antibodies to the Pfalhesin peptide of the human aniontransporter, band3, were measured by the same method. The magnitude of this antibody response did not correlate with neither age nor clinical protectionen_US
dc.identifier.urihttp://khartoumspace.uofk.edu/123456789/17361
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPlasmodiumen_US
dc.subjectproteinen_US
dc.subjectfalciparum erythrocyteen_US
dc.titleAntibody Reactivity to Conserved Linear Epitopes of Plasmodium Falciparum Erythrocyte Membrane Protein 1 (PfEMP1)en_US
dc.typePublicationen_US

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