Interplay between AMA1 immunisation and parasite challenge leads to protection against malaria infection in rhesus macaques
No Thumbnail Available
Date
2015-11-12
Authors
Abdel Hamid, Muzamil M.
J Remarque, Edmond
Faber, Bart W
Journal Title
Journal ISSN
Volume Title
Publisher
university of khartoum
Abstract
Plasmodium knowlesi (Pk), a simian malaria parasite, is a
suitable primate model for Plasmodium falciparum (Pf),
and it was recently identified as the fifth human malaria
parasite [1]. To test the ability of yeast-expressed
PkAMA1 (Figure 1) to protect rhesus macaques upon
challenge with Pk, six healthy rhesus monkeys were
vaccinated with PkAMA1 and six control monkeys were
vaccinated with PfAMA1 formulated in an oil in water
adjuvant [2]. All monkeys received three i.m. vaccinations
at 4 week intervals
Description
Keywords
Interplay between AMA1 immunisation and parasite challenge leads to protection against malaria infection in rhesus macaques