T-Cell Responses in Human Leishmaniasis
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Date
2015-12-01
Authors
Elhassan, Ahmed M.
Kharazmi, A.
Gasim, S.
Journal Title
Journal ISSN
Volume Title
Publisher
UOFK
Abstract
In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-γ response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-γ production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-γ and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.
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Keywords
T-Cell Responses, Human Leishmaniasis