T-Cell Responses in Human Leishmaniasis

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dc.FacultyEndemic Diseasesen_US
dc.contributor.authorElhassan, Ahmed M.
dc.contributor.authorKharazmi, A.
dc.contributor.authorGasim, S.
dc.contributor.otherMolecular Biologyen_US
dc.date1999-01
dc.date.accessioned2015-12-01T11:43:04Z
dc.date.available2015-12-01T11:43:04Z
dc.date.issued2015-12-01
dc.date.submitted2015
dc.description.abstractIn the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-γ response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-γ production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-γ and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.en_US
dc.identifier.urihttp://khartoumspace.uofk.edu/123456789/17393
dc.language.isoenen_US
dc.publisherUOFKen_US
dc.subjectT-Cell Responsesen_US
dc.subjectHuman Leishmaniasisen_US
dc.titleT-Cell Responses in Human Leishmaniasisen_US
dc.typePublicationen_US

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